急性肝衰竭

Acute Liver Failure
Roger S. Williams
Institute of Hepatology, UCL Medical School, London
On the third day of APASL, Professor Roger S. Williams made a report on acute liver failure. He presented three important phases in the management schedule:

1)Early identification of causes requiring specific treatment.

2)Institution of early monitoring and optimal intensive care for multi-organ involvement to improve chances of spontaneous recovery or of transplantation.  Infections need to be treated aggressively along with maintenance of the circulation and support of the organ function .

3)Assessment of the need for transplantation based on strong positive predictive values provided by the King’s or Clichy Criteria. Living Donor Liver Transplantation is encouraging. The MARS artificial support device may be used as a bridge to transplant.

    At last, he said that challenges to future research included the significant number of cases where no aetiology was identifiable.

在APSAL大会第三天，Roger S. Williams教授做了关于急性肝衰竭的大会报告。他提出了ALF处理过程中的3个重要阶段：1）对需要特异性治疗的肝衰竭病因的早期鉴别。2）早期监护机构及多器官受累时的重症监护。3）根据King’s 或Clichy标准对是否需要肝移植的评估。而下一步研究面临的挑战在于相当一部分未能明确ALF病因的病例。进一步明确其病因有利于不同处理措施的选择。